7th Conference Program

7th ISABS Conference

"7th ISABS Conference in Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures in Translational Medicine"
Bluesun hotel ELAPHUSA, Bol, Island of Brač, Croatia, June 20-24, 2011

Conference program scheme is available here (PDF 184 KB).

Sunday, June 19, 2011

18:00 - 20:00 Registration and Poster and Sponsors’ booth Setup
(in front of the „Brač“ conference room)

Monday, June 20, 2011

08:00 - 18:00 Registration
08:00 - 11:00 Poster Setup (Conference floor) Introductory Plenary Session („Brač“ conference room)
08:30 Directors’ introductory remarks
08:35 Peter Underhill (Stanford University Medical Center, Stanford, CA, USA) A Y chromosome
perspective of post-glacial human migrations in Southeast Europe
09:05 Doron Lancet (The Weizmann Institute of Science, Rehovot, Israel) Variogenomics–human individual variation as the cornerstone of next-generation genomics
09:35 Giulio Pompilio (University of Milan, Milan, Italy)
Cell therapy for myocardial refractory ischemia with bone-marrow derived CD133+ cells:
translational path and preliminary results
10:05 Coffee Break
10:15 Inauguration of the conference
10:30 Keynote Address - Manfred Kayser (Erasmus MC - University Medical Center Rotterdam,Rotterdam, Netherlands)Human appearance: genetic basis, DNA prediction, and forensic application
11:10 Malcolm Brenner (Baylor College of Medicine, Houston, TX, USA)Implementing complex biological therapies in academic centers
11:40 Henry C. Lee (The Henry C. Lee College of Criminal Justice and Forensic Sciences, University of New Haven, West Haven, CT, USA) DNA evidence in high profile cases
12:10 Adjourn
12:30-14:30 Sponsor Exhibit Opening and Poster Presentation (Conference floor)

Parallel Session: Forensic Science 1 („Brač 2“ conference room)

15:00 Introduction from the chair (Katja Drobnič and Timothy Palmbach)
15:05 Timothy Palmbach (The Henry C. Lee College of Criminal Justice and Forensic Sciences,
University of New Haven, West Haven, CT, USA) A retrospective analysis of cold-case investigations
15:40 Moses Schanfield (George Washington University, Washington, DC, USA) A review and update of forensic statistics
16:15 Vedrana Škaro (Selected Oral Presentation) (Genos Ltd, Forensic DNA Laboratory, Zagreb,
Croatia) Mitochondrial DNA polymorphisms in 312 individuals of Croatian population determined by
the mtHV+ HaploArray 105 probe panel targeting 61 hypervariable and coding region sites
16:30 Katja Drobnič (Faculty of Criminal Justice and Security, UM and National forensic laboratory, MNZ Slovenia) Perspectives and pitfalls of mRNA profiling for identification of menstrual blood and vaginal
secretion
17:00 Theresa Caragine (Office of Chief Medical Examiner, New York, NY, USA) Estimating the number of contributors to two-, three-, and four-person mixtures containing DNA in high template and low template amounts
17:30 Discussion

Parallel Session: Workshop on Biomathematical Modeling and Cancer Immunotherapy 1 („Brač 1“ conference room)

15:00 Chairs’ overview of Workshop goals (Gunnar Kvalheim and Yuri Kogan)
15:15 Stanimir Vuk-Pavlović (College of Medicine, Mayo Clinic, Rochester, MN, USA) The fall and rise of immunity
15:45 Gunnar Kvalheim (Norwegian Radium Hospital, University of Oslo, Oslo, Norway) Dendritic cell based cancer vaccines targeting tumor stem cells
16:15 Yuri Kogan (Institute for Medical BioMathematics, Bene Ataroth, Israel)
Improving alloreactive CTL immunotherapy for malignant gliomas using a mathematical model
16:45 Malcolm Brenner (Baylor College of Medicine, Houston, TX, USA) Increasing safety and practicality of cell-based immunotherapy
17:15 Filippo Castiglione (NRC Institute for Computing Applications, Rome, Italy) Mathematical modeling and optimal control of dendritic cell transfection cancer immunotherapy
17:45 Discussion

18:20-19:30 Poster presentation I (Conference floor)
19:30-21:30 Meet the Professor I, wine and cheese (swimming pool)

Tuesday, June 21, 2011

Parallel Session: Molecular Medicine 1 („Brač 1“ conference room)

08:30 Introduction from the chair (Dušica Babović-Vuksanović and Henry Erlich)
08:35 Dušica Babović-Vuksanović (College of Medicine, Mayo, Clinic, Rochester, MN, USA) Clinical genetics in individualized medicine
09:05 Mark Stoneking (Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany) High-throughput sequencing of complete human mtDNA genomes: insights into population history and heteroplasmy
09:35 Henry Erlich (Roche Molecular Systems, Pleasanton, CA, USA) HLA polymorphism, disease susceptibility, and pharmacogenetics
10:05 Renato Polimanti (YIA)(University of Rome "Tor Vergata", Rome, Italy) Role of the glutathione S-transferase gene polymorphisms as markers in complex diseases
10:20 Pauline Rudd (The National Institute for Bioprocessing Research and Training, Dublin,
Ireland) Systems glycobiology: From genome to glycome an integrated strategy for identifying and screening potential clinical markers
10:50 Christopher Evans (Center for Advanced Orthopaedic Studies, Harvard Medical School,
Boston, MA, USA) Gene therapy for bone and cartilage healing
11:20 Giorgio Palù (University of Padova, Padova, Italy)
Virus-host interactions: The role of microRNA in tumorigenesis and immune evasion
11:50 Discussion

Parallel Session: Workshop on Legal and Ethical Aspects of DNA Forensic Analysis („Brač 2“ conference room)

08:30 Introduction from the chair (David Kaye and Frederick Bieber)
08:35 Dragan Primorac (University of Split and University of Osijek, Croatia; The Pennsylvania State University and University of New Haven, USA) From dust to dust: Forensic DNA analysis
09:15 Frederick Bieber (Harvard Medical School and Brigham and Women's Hospital, Boston, MA,
USA) Forensic analysis of DNA data banks: process, progress, and prospects
09:55 David Kaye (Eberly College of Science, Penn State University, PA, USA) Kinship Matching with DNA Databases (aka “Familial Searching”): Legal and Ethical Arguments
10:35 Christopher Asplen (Gordon Thomas Honeywell Governmental Affairs, Washington, DC and
DNA 4 Africa, Chalfont, PA, USA) International perspectives on forensic DNA databases
11:05 Discussion

Parallel Session: Anthropological Genetics („Brač 2“ conference room)

15:00 Introduction from the chair (Daniel Vanek and Richard Villems)
15:05 Daniel Vanek (Forensic DNA Service, Prague, Czech Republic) Famous DNA lineages from the perspective of archaeogenetics and genetic genealogy
15:35 Šimun Anđelinović (Selected Oral Presentation) (University Hospital Split, Split, Croatia) Anthropological, genetic and chemical analysis of ancient skeletons from southern Croatia
15:50 Richard Villems (University of Tartu and Estonian Biocentre, Tartu, Estonia) An attempt to place the Balkans on the canvas of genetic variation of West Eurasia and North Africa
16:20 Brendan Keating (Selected Oral Presentation) (University of Pennsylvania, Philadelphia, PA,
USA) Genome-wide 200,000 SNP array for profiling of external visible traits, kinship and ancestry
16:35 Kristin Young (University of Kansas Medical Center, Kansas City, KS, USA)
Basques in the genetic landscape of Europe
17:05 Damir Marjanović (Institute for Genetic Engineering and Biotechnology, Sarajevo, Bosnia and Herzegovina and Genos, Zagreb, Croatia) DNA analysis of ancient skeletal remains from old Bosnian graves
18:05 Discussion

Parallel Session: Workshop on Biomathematical Modeling and Cancer Immunotherapy 2 („Brač 1“ conference room)

15:00 Introduction from the chair (Filippo Castiglione and Zwi Berneman)
15:05 Moran Elishmereni (Institute for Medical BioMathematics, Bene Ataroth, Israel) A validated mathematical model of systemic IL-21 immunotherapy in solid cancers for the design of beneficial treatment regimens
15:40 Zwi Berneman (University of Antwerp, Antwerp, Belgium) Dendritic cell vaccination in leukemia and AIDS
16:15 Karin HaLevi (Institute for Medical BioMathematics, Bene Ataroth, Israel) A method for in-treatment personalization of cancer immunotherapy
16:50 Samuel Volchenboum (University of Chicago, Chicago, IL, USA) New systems biology tools for cancer diagnostics
17:25 Stipan Jonjić (Faculty of Medicine, University of Rijeka, Rijeka, Croatia) How viruses can teach us to make better vaccines and vaccine vectors
17:35 Discussion and drafting conclusions

20:00 Welcome Reception (Borak Beach Restaurant, located by the sea, right below the promenade, approximately 50 meters from hotel „Elaphusa“)

20:20 Conferring Young Investigator Awards

Wednesday, June 22, 2011

9:00 - 16:30 Half-day excursion
18:00 Special ISABS lecture Jakov Dulčić (Institute of Oceanography and Fisheries, Split) The open sea (a movie) followed by lecture Marine Science and Croatian Naturalists: 430 Years of Adriatic Marine Science
18:45 ISABS Annual Meeting („Brač 2“ conference room)

Thursday, June 23, 2011

Parallel Session: Forensic Science 2 („Brač 2“ conference room) Workshop on Legislation Pertinent to DNA Databases
08:30 Introduction from the chair (Antti Sajantila and Mitchell Holland)
08:35 Mitchell Holland (Eberly College of Science, Penn State University, PA, USA) Second generation sequencing allows for mtDNA mixture deconvolution and high resolution detection of heteroplasmy
09:10 Sree Kanthaswamy (California National Primate Research Center, University of California,
Davis, CA, USA) Non-human forensic genetics
09:45 Mark Barash (YIA) (Bond University, Gold Coast, Australia) Identification of SNPs involved in determination of facial morphology
10:00 Marilyn Menotti-Raymond (National Cancer Institute, Frederick, MD, USA) Genetics of coat patterns in the domestic cat
10:35 Antti Sajantila (University of Helsinki, Helsinki, Finland) Post mortem pharmacogenomics - concepts, cases and research
11:10 Zoran Budimlija (Office of Chief Medical Examiner, New York, NY, USA) Chimerism and forensics–Examples and importance
11:45 Discussion

Parallel Session: Advances in Noninvasive Prenatal Diagnosis in First Trimester („Brač 1“ conference room)

08:30 Introduction from the chair (Eliezer Shalev)
08:35 Eliezer Shalev (Human Genetic Center, Ha’emek Medical Center, Afula and Technion-Israel Institute of Technology, Haifa, Israel) Early prenatal diagnosis–an overview
09:10 Ron Tepper (Sapir Medical Center, Kfar Saba, Israel) Early fetal 3D ultrasound examination
09:45 Stavit Shalev (Human Genetic Center, Ha’emek Medical Center, Afula and Technion-Israel Institute of Technology, Haifa, Israel) Genetic assessment of pregnancies with increased nuchal translucency and normal karyotype
10:20 Esther Guetta (Danek Gertner Institute of Human Genetics, Sheba Medical Center,
Tel-Hashomer, Israel) Application of Free Nucleic acids in Maternal Blood for Non-Invasive Prenatal Diagnosis: Techniques, Advantages and Limitations
10:55 Simcha Yagel (Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel)
First trimester screening for trisomy 21 with ultrasound and biochemical markers vs. fetal cell free nucleic acids in maternal serum
11:30 Ofer Klein (Rebecca Sieff Medical Center and BioCep, Ltd., Safed, Israel) CEP as innovative method for isolation of fetal nucleated red blood cells for noninvasive prenatal diagnosis
12:05 Discussion

Technical Workshop („Brač 2“ conference room)

12:00-12:20 Stephen Lupton (Promega GmbH)
Optimization of the forensic workflow with innovations from Promega: automated sample prep and new kits for STR-Analysis
12:20-12:40 Hellwig Daniel (Sorenson Forensics, Salt Lake City, UT, USA) Sorenson forensics investigative leadsm: determination of suspect genetic ancestry from crime scene evidence

Parallel Session: ESF Workshop on protein glycosylation in diagnostics and therapy („Brač 1“ conference room)

15:00 Introduction from the chair (Nicolai Bovin and Gordan Lauc)
15:05 Nicolai Bovin (Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russian
Federation) Diagnostic potential of antiglycan antibodies
15:35 Thierry Hennet (Institute of Physiology, University of Zürich, Zürich, Switzerland) Congenital disorders of glycosylation, from genotypes to therapies
16:05 Gordan Lauc (Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia) Antennary fucosylation of plasma proteins is a reliable diagnostic marker for HNF1A-MODY: Translation of a glycome-GWAS hit into a clinically useful screening tool
16:35 Erdmann Rapp (Max Planck Institute for Dynamic of Complex Technical Systems in Magdeburg, Germany) Tools for the glycome analysis in the post-genomic era
17:05 Manfred Wuhrer (Leiden University Medical Center, Leiden, The Netherlands) Glycosylation profiling for biomarker discovery of autoimmune and alloimune diseases
17:35 Hakon Leffler (Lund University Hospital Sölvegatan, Lund, Sweden) Galectin binding glycoforms of serum proteins, a functional biomarker in cancer and inflammation
18:05 Discussion

Parallel Session: Cell Therapy („Brač 2“ conference room)

15:00 Introduction from the chair (Andre Terzic and Hennig Madry)
15:05 Andre Terzic (College of Medicine, Mayo Clinic, Rochester, MN, USA) Stem cell platforms for heart repair
15:40 Jef Pinxteren (ReGenesys, Heverlee, Belgium) Adult stem cells as biologics delivery platform for ischemic injury
16:15 Martina Smolić (YIA) (University of Connecticut Health Center, Farmington, CT, USA; University of Osijek, Osijek, Croatia) Low CYP2E1 gene expression permits pharmacological selection of transplanted human hepatocytes in vivo
16:30 Pavel Čapek (Selected Oral Presentation) (Charles University, Prague, Czech Republic) Hypertrophic cardiomyopathy: from mutation to functional analysis of defected protein
16:45 Dennis Gastineau (College of Medicine, Mayo Clinic, Rochester, MN, USA) A day at the Human Cell Therapy Laboratory, Mayo Clinic
17:20 Henning Madry (Saarland University Hospital and Saarland University Faculty of Medicine, Homburg, Germany) Regeneration of cartilage defects using gene-based approaches and tissue engineering of cartilage based on genetically modified cells
17:55 Discussion

18:10-19:30 Poster presentation II (Conference floor)

19:30-21:30 Meet the Professor II, wine and cheese (Conference floor)

Friday, June 24, 2011

Parallel Session: Molecular Medicine 2 („Brač 1“ conference room)

08:30 Introduction from the chair (Christopher Evans and Carmen Terzic)
08:35 Arezou Ghazani (Harvard Medical School and Massachussetts General Hospital, Boston, MA, USA) Advances in Molecular Diagnostics: Role of Nanotechnology and Future Perspectives
09:10 Artemis Simopoulos (The Center for Genetics, Nutrition and Health, Washington, DC, USA) Nutrigenetics and nutrigenomics in personalized nutrition and medicine
09:45 Carmen Terzic (College of Medicine, Mayo Clinic, Rochester, MN, USA) Prediction of pathophenotype through transcriptome deconvolution
10:20 George Wu (University of Connecticut Health Center, Farmington, CT, USA) A practical immunocompetent animal model of hepatitis C viral infection
10:55 Christopher Evans (Center for Advanced Orthopaedic Studies, Harvard Medical School, Boston, MA, USA) Gene therapy for arthritis
11:30 Discussion

Parallel Session: NextGen Sequencing („Brač 2“ conference room)

08:30 Introduction from the chair (George Vasmatzis)
08:35 David I. Smith (College of Medicine, Mayo Clinic, Rochester, MN, USA) The Next Generation Sequencing Revolution
09:00 David I. Smith (College of Medicine, Mayo Clinic, Rochester, MN, USA) Next Generation Sequencing of oropharingeal cancers
09:25 Henry Erlich (Roche Molecular Systems, Pleasanton, CA, USA) Resolution of DNA mixtures and degraded DNA by Next-Generation Sequencing
09:55 Jean-Pierre Kocher (College of Medicine, Mayo Clinic, Rochester, MN, USA) Integration of multiple data types obtained from genomics experiments: challenges and opportunities
10:25 Rebecca Just (YIA) (Armed Forces DNA Identification Laboratory, Rockville, MD, USA; University of Maryland, College Park, MD, USA) Investigation of next generation sequencing for mitochondrial DNA applications in forensics
10:40 George Vasmatzis (College of Medicine, Mayo Clinic, Rochester, MN, USA) Molecularly-defined cancer subtypes using NextGen Sequencing
11:10 Matthew Ferber (College of Medicine, Mayo Clinic, Rochester, MN, USA) Clinical NextGen Sequencing of hereditary colon cancer genes
11:40 Discussion

Conclusion of the Conference

Announcement of the next ISABS Conference

12:30-14:00 Poster removal